Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.

Characterization of Two Splice Variants of Human Organic Anion Transporting Polypeptide 3a1 (oatp3a1) Isolated from Human Brain

In the present study we have isolated two splice variants of the organic anion transporting polypeptide 3A1 (OATP3A1_v1 and OATP3A1_v2) from human brain. OATP3A1_v2 lacks 18 amino acids at the C-terminal end (692 aa) but is otherwise similar in sequence as OATP3A1_v1 (710 aa). OATP3A1_v1 exhibits a wide tissue distribution with expression in testis, various brain regions, heart, lung, spleen, p...

Frequencies of two functionally significant SNPs and their haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in six ethnic groups of Pakistani population

Objective(s):Organic anion transporter polypeptide 1B1 (OATP1B1) encoded by solute carrier organic transporter 1B1 (SLCO1B1) gene; a transporter involved in the uptake of drugs and endogenous compounds is present in hepatocyte sinusoidal membrane. Aim of this study was to investigate the frequencies of functionally significant SNPs (388A>G and 521T>C) and their haplotypes in 6 ethnic groups of ...

Inhibition of Human Organic Anion Transporting Polypeptide (OATP) -1B1 and -1B3 by Tyrosine Kinase Inhibitors

Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations.

Hepatic uptake of albumin-bound amphipathic organic cations has been suggested to be mediated by multispecific bile salt and organic anion transport systems. Therefore, we investigated whether the recently cloned rat organic anion transporting polypeptides 1 and 2 as well as the human organic anion transporting polypeptide might be involved in the hepatocellular uptake of bulky type II organic ...

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

Fexofenadine, a nonsedating antihistamine, does not undergo significant metabolic biotransformation. Accordingly, it was hypothesized that uptake and efflux transporters could be importantly involved in the drug's disposition. Utilizing a recombinant vaccinia expression system, members of the organic anion transporting polypeptide family, such as the human organic anion transporting polypeptide...